Synthesis of Pyrimidine Derivatives
نویسندگان
چکیده
منابع مشابه
Synthesis and antibacterial properties of pyrimidine derivatives.
In this study, a series of syntheses was conducted on the pyrimidine system, obtaining bisulfite carboxyl derivatives 4 and hydroxy derivatives 5. In addition, a series of syntheses were carried out as a result of which both alkyl and aromatic amines were obtained. Then, the attempt was made to cyclize these amines in the Mannich reaction to pyrimido[4,5-d]pyrimidines 11, 12. After determinatio...
متن کاملDrug Synthesis Synthesis and Antibacterial Properties of Pyrimidine Derivatives
In this study, a series of syntheses was conducted on the pyrimidine system, obtaining bisulfite carboxyl derivatives 4 and hydroxy derivatives 5. In addition, a series of syntheses were carried out as a result of which both alkyl and aromatic amines were obtained. Then, the attempt was made to cyclize these amines in the Mannich reaction to pyrimido[4,5-d]pyrimidines 11, 12. After determinatio...
متن کاملSynthesis, Antibacterial and Anticancer Evaluation of Some Pyrimidine Derivatives
Abstarct: A series of some new pyrimidine derivatives were synthesized via the reaction of ethyl cyanoacetate with thiourea and the appropriate aldehydes namely 2-methyl-benzaldehyde and 2-methoxy-benzaldehyde to give 1a,b. Compounds 1a,b were chlorinated to give the chloro compounds 2a,b then condensation of 2a,b via different reagents gave compounds 3-5. Compound 4b reacted with acetic anhydr...
متن کاملSynthesis and biological activity of some pyrimidine derivatives.
Objectives: To synthesize a variety of pyrimidine analogs, 3, 4, 5, 6(aed), 7(aed) and their anticonvulsant and antioxidant activity was determined. Methods: Using 5-bromo-2,4-dichloropyrimidine and hydrazine hydrate, new compounds were synthesized. The structures of all the new compounds are established on the basis of FT-IR, H NMR and mass spectral data. Anticonvulsant study was done by MES s...
متن کاملSynthesis of Pyrimidine Incorporated Piperazine Derivatives and their Antimicrobial Activity
Thiophene substituted chalcones (1a-e) were cyclised with thiourea in presence of potassium hydroxide to get 4-substituted-6-(thiophen-2-yl)pyrimidine-2-thiols (2a-e) which were then stirred with methyl iodide to obtain 4-substituted-2-(methylsulfanyl)-6-(thiophen-2-yl)pyrimidines (3a-e). Compounds (3a-e) were refluxed with different N-methylpiperazine and N-phenylpiperazine to afford 4-substit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Synthetic Organic Chemistry, Japan
سال: 1969
ISSN: 0037-9980,1883-6526
DOI: 10.5059/yukigoseikyokaishi.27.169